Hyaluronic acid (HA) is a vital molecule with an essential role in various biological processes, from maintaining skin hydration to lubricating joints. It’s no surprise that HA is widely used in skincare products and dietary supplements; however, its effectiveness can vary significantly depending on the method of application. Today, we want to answer two important questions: how should hyaluronic acid be used, and how can we maximize its benefits for our bodies?

Let’s take a closer look at how to make the most of hyaluronic acid, exploring the most innovative application methods and key differences that allow this powerful substance to become a true elixir for well-being.

How to use hyaluronic acid: a complete guide

Hyaluronic acid can be used in several forms, each offering distinct benefits:

  • topical (creams and serums) – Applied directly to the skin to deliver surface-level hydration and improve elasticity, making it perfect for cosmetic and anti-aging treatments;
  • oral (capsules, tablets) – Taken as a supplement, it helps promote skin hydration and supports joint health from within;
  • sublingual – Placed under the tongue for rapid, direct absorption into the bloodstream;
  • joint Injections – Injected directly into joints to help alleviate joint discomfort and improve mobility;
  • dermal Fillers – Used as targeted injections on the face or body to smooth and contour, addressing aesthetic concerns.

Hyaluronic Acid is most commonly used topically (in serums and creams) or systemically (in supplements).

In topical applications, it is known for its ability to retain moisture in the skin, enhancing hydration and firmness. However, this article focuses on using hyaluronic acid systemically, from within, to achieve benefits across the entire body, including the skin, eyes, hair, mucous membranes, connective tissues, and joints.

One of the most targeted and powerful ways to use hyaluronic acid is through injections. These are direct injections into the joints, commonly used to treat issues like osteoarthritis or cartilage degeneration. Their function is simple yet effective: to restore the natural lubrication of the joints, reducing friction between bones and improving mobility. Injections are especially used in orthopedic and sports medicine, acting as a kind of “lubricant” for the body, relieving pain, and delaying the need for more invasive interventions. If your goal is to address joint issues quickly and specifically, injections offer a highly targeted and immediate solution.

Injections, however, besides being a very specific and somewhat uncomfortable method of administration, also require a medical prescription. Here, instead, we want to discuss accessible alternatives that have proven effective for a wide range of situations: hyaluronic acid supplements.

How effective are they? Previously, analyzing hyaluronic acid in tablet form, we discussed the molecular weight of the substance, but this alone doesn’t explain why some supplements work better than others.

What really makes the difference is how hyaluronic acid is absorbed by the body, an essential factor that greatly impacts results. This is where the concept of bioavailability becomes crucial.

How to use hyaluronic acid: bioavailability

When the goal is global well-being, involving not only the joints but also the skin and other tissues, it is important to choose carefully how to use hyaluronic acid. In this case, systemic absorption becomes fundamental, and this is where the key concept of bioavailability comes into play.

Bioavailability is the technical term that indicates the percentage of a substance that actually enters the bloodstream and becomes available to the body after administration. This concept is essential when we talk about effectiveness, because not all routes of administration allow hyaluronic acid to be absorbed in the same way.

These differences can radically change the effectiveness of hyaluronic acid, and that is why we must make a clear distinction between the different methods of intake.

Intestinal absorption: a complex journey

Consider, for instance, hyaluronic acid taken orally in capsules or powders.

While this method may seem straightforward and convenient, the journey of hyaluronic acid through the digestive system is quite intricate.

Hyaluronic acid consists of macromolecules that cannot penetrate the pores of our intestines. Once ingested and reaching the stomach, it struggles to enter the bloodstream, which is essential for delivering it to various organs. Products containing hyaluronic acid in its natural form often prove ineffective because only a small fraction of the active ingredient is absorbed.

Imagine the intestines as a soccer net: when a goal is scored, the ball ends up in the net, which has holes that prevent it from passing through. In a similar way, the large molecules of hyaluronic acid cannot cross the intestinal barrier, and enzymes and gastric acids metabolize and destroy it before it can be utilized.

As a result, bioavailability is significantly reduced, with a very small percentage of the substance actually reaching the bloodstream and tissues. Consequently, the intestinal journey greatly influences the amount of active ingredient that arrives at its planned destination.

This means that while orally ingested hyaluronic acid may provide some benefits, these effects could be less pronounced or take longer to be visible. Its passage through the body is slow and fragmented, which is why alternative solutions are being sought.

Hydrolysis is the solution

Let’s imagine again the soccer net analogy: if, instead of a soccer ball, we kicked a ping pong ball, it would easily pass through the net. This illustrates what is needed for hyaluronic acid to cross the intestinal barrier: smaller molecules.

This challenge has been addressed through hydrolysis, a natural technique that reduces the size of hyaluronic acid molecules, allowing them to navigate through the intestinal pores and enter the bloodstream on their way to target organs.

Sublingual absorption: a significant advantage

The hydrolysis of hyaluronic acid, which reduces the size of its molecules, enables a more smooth and effective method of absorption: the sublingual route.

In this method, hyaluronic acid is placed under the tongue, where the mucous membranes rich in blood vessels absorb it directly, bypassing the digestive system. This means the molecule travels much faster into the bloodstream, and if any portion of the substance is swallowed, it remains intact and can still cross the intestinal barrier without degradation.

As a result, this approach leads to a bioavailability that can reach nearly 100%.

To sum up, this approach offers two main advantages:

  1. speed and potency – due to direct absorption, sublingual hyaluronic acid enters the bloodstream almost immediately, providing rapid and visible results. Whether you’re looking to enhance skin elasticity, support joint health, or nourish connective tissues, the effects are quicker and more pronounced;
  2. enhanced effectiveness – by bypassing the stomach and intestines, the molecule retains its chemical integrity and reaches tissues in a purer, more active form. This results in a more strong action compared to oral intake, making the sublingual method a superior choice for those seeking tangible benefits in less time.

How to use pure hyaluronic acid

Combining pure hyaluronic acid with the sublingual administration method represents a breakthrough for those seeking quick and concrete results.

For skin, hair, eyes, mucous membranes, and connective tissues, choose Osidra.

For joint health, select Cartial D.

The advanced biotechnologies used in these two products highlight how the method of administration can significantly impact the effectiveness, distinguishing between products that merely promise results and those that truly deliver.

How to Use Them? It’s Quite Simple: The recommended dosage for both Osidra and Cartial D ranges from 1 to 3 ml per day, with treatment cycles lasting three months.

How to take Osidra:

  • 1 ml per day = 5 total puffs.
  • 2 ml per day (optimal dosage) = 1 ml in the morning and 1 ml in the evening (totaling 10 puffs per day, 5 in the morning and 5 in the evening).
  • 3 ml per day (intensive dosage) = 7 puffs in the morning and 8 puffs in the evening.

How to take Cartial D:

  • 1 ml per day = 11 total puffs.
  • 2 ml per day (optimal dosage) = 1 ml in the morning and 1 ml in the evening (totaling 22 puffs per day, 11 in the morning and 11 in the evening).
  • 3 ml per day (intensive dosage) = 16 puffs in the morning and 17 puffs in the evening.

You just have to spray the gel under your tongue and hold it in your mouth for about 60 seconds.

Simple, Immediate, Effective: This attention to detail makes Osidra and Cartial D unique solutions in the world of hyaluronic acid supplements. Our supplements not only enhance the action of hyaluronic acid but also preserve its chemical integrity, providing more effective results compared to traditional oral supplements, ensuring superior bioavailability and rapid absorption.

This translates into tangible benefits for the body, including improved skin tone and hydration, as well as support for connective tissues and epithelial cells. Consider the significant advantages for vaginal mucosa for those experiencing dryness and for joints in individuals with osteoarthritis.

  • OSIDRA 50 ml sublingual spray - EIDON salus
    This product has multiple variants. The options may be chosen on the product page

    OSIDRA 50 ml

    30,00 163,80 
  • CARTIAL D 50 ml, hyaluronic acid - EIDON salus
    This product has multiple variants. The options may be chosen on the product page

    CARTIAL D 50 ml

    28,00 151,80 

Thanks to sublingual administration, Osidra and Cartial D are essential allies for those seeking an advanced and innovative solution that acts quickly and with greater intensity, providing visible improvements in a shorter time frame.

Conclusions

Whether you choose to use hyaluronic acid topically, through targeted injections, or with supplements, it’s important to remember that each method serves a specific purpose.

For a health-conscious consumer aiming for overall improvement, ranging from skin hydration to joint lubrication, bioavailability is the critical factor to consider, as it translates the product’s promises into actual effectiveness.

Imagine taking a supplement that claims to enhance skin hydration or joint mobility. If hyaluronic acid is absorbed ineffectively (as can happen with some oral supplements), the results will be weak or even imperceptible. In contrast, higher bioavailability, such as that offered by the sublingual absorption of Osidra and Cartial D, ensures that the active ingredient reaches its destination in maximum concentration to truly make a difference.

Therefore, when we ask how to use hyaluronic acid for optimal results, the answer lies not only in “what” we use but also in “how.” Sublingual absorption represents a revolution in the realm of supplements, providing superior efficacy compared to traditional intestinal administration methods.